Kamora ts'enyo e matla kapa e sa foleng ea thibelo ea epidermal, mokhoa oa ho lokisa letlalo o potlakisa tlhahiso ea keratinocyte, o khutsufatse nako ea ho khutlisa lisele tsa epidermal, 'me o buelle tlhahiso le tokollo ea li-cytokine, e leng se bakang hyperkeratosis le ho ruruha ha letlalo. . Sena se boetse se tloaelehile ka matšoao a letlalo le omeletseng.
Ho ruruha ha sebaka sa heno ho ka boela ha mpefatsa ho omella ha letlalo, ha e le hantle, ho senyeha ha mokoallo oa epidermal ho khothalletsa ho qaptjoa le ho lokolloa ha letoto la li-cytokine tsa pro-inflammatory, tse kang IL-1he TNF, e le hore lisele tsa 'mele tsa phagocytic, haholo-holo li-neutrophils, li timetsoe. Ka mor'a ho khahloa ke sebaka se omileng, ka mor'a ho fihla moo ho eang teng, li-neutrophils li hlahisa leukocyte elastase, cathepsin G, protease 3, le collagenase ka har'a lisele tse potolohileng, 'me li theha le ho matlafatsa protease ka keratinocyte. Liphello tse ka bang teng tsa tšebetso e feteletseng ea protease: 1. Tšenyo ea lisele; 2. Ho lokolloa ha li-cytokine tsa pro-inflammatory; 3. Ho senyeha pele ho nako ha li-contacts tsa sele-to-cell tse khothalletsang mitosis ea lisele. Mosebetsi oa proteolytic enzyme letlalong le omeletseng, le ka 'nang la ama methapo ea kutlo e epidermis, e amahanngoa le pruritus le bohloko. Tšebeliso ea lihlooho tsa tranexamic acid le α1-antitrypsin (protease inhibitor) ho xerosis e sebetsa hantle, ho fana ka maikutlo a hore xeroderma e amahanngoa le mosebetsi oa proteolytic enzyme.
Dry epidermis e bolela horetšitiso ea letlalo e ferekanngoa, lipids lia lahleheloa, liprotheine lia fokotseha, 'me mabaka a ho ruruha a sebakeng seo a lokolloa.Ho omella ha letlalo ho bakoang ke ho senyeha ha mokoalloe fapane le ho omella ho bakoang ke ho fokotseha ha sebum secretion, 'me phello ea tlatsetso e bonolo ea lipid hangata e hlōleha ho finyella litebello. Litlolo tse nang le mongobo tse ntlafalitsoeng bakeng sa tšenyo ea mokoallo ha lia lokela feela ho tlatselletsa lintho tse mongobo tsa stratum corneum, joalo ka liceramide, lintho tsa tlhaho tse mongobo, joalo-joalo, empa hape li nahanele litlamorao tsa karohano ea antioxidant, anti-inflammatory le anti-cell, ka hona e fokotsa phapang e sa phethahalang. boemo ba keratinocyte. Ho omella ha letlalo la mokoallo hangata ho tsamaisana le pruritus, 'me ho eketsoa ha mesebetsi ea antipruritic ho lokela ho nkoa.
Nako ea poso: Jun-10-2022
