Ntlha ea pele ea botsofali ba letlalo:
Mahlaseli a UV, ho nka linepe
70% ea botsofali ba letlalo e simoloha ho photoaging
Mahlasedi a UV a ama collagen 'meleng ea rona, e leng se bolokang letlalo le shebahala le le lecha. Haeba collagen e fokotseha, letlalo le tla ba le ho se tenyetsehe ho fokolang, ho sotheha, ho fifala, ho se leka-lekane ha letlalo, ho ba le pigmentation e ngata, pigmentation le mathata a mang a letlalo.
Lehlasedi le pharaletseng la letsatsi le arotsoe ka UVA le UVB. Mahlasedi a UVB a na le maqhubu a makgutshwane mme a ka tjhesa lera le ka hodimo la letlalo la rona feela, a sa kgone ho kenella ka botebo letlalong; leha ho le jwalo, mahlaseli a UVA a na le maqhubu a malelele mme a ka kenella ka khalase mme a teba letlalong, qetellong a fokodisa collagen mme a lebisa ho hola ha matheba.
Ka mantsoe a bonolo, UVA e lebisa botsofaling, UVB e lebisa ho cheng, 'me khanya ea ultraviolet e ka senya DNA ea sele, ea fokotsa ts'ebetso ea fibroblast, 'me tlhahiso ea collagen ea thibeloa, e leng se lebisang phetohong ea sele, botsofaling le apoptosis. Kahoo, UV e hohle, ebang ke letsatsi kapa maru, u hloka ho etsa mosebetsi o motle oa tšireletso letsatsing.
Ntlha ea bobeli ea bohlokoa ka ho fetisisa botsofaling ba letlalo
Li-radical tsa mahala tse nang le oxidative
Lentsoe la bohlokoa bakeng sa li-free radicals ke 'oxygen'. Re hema hoo e ka bang karolo ea 98 ho isa ho 99 lekholong ea oksijene nako le nako ha re hema; e sebelisetsoa ho chesa lijo tseo re li jang le ho lokolla limolek'hule tse nyane hore lisele tsa rona li sebetse, 'me e ntša matla a mangata ho etsa hore mesifa ea rona e sebetse.
Empa mohlomong 1% kapa 2% ea oksijene e khetha tsela e fapaneng le e kotsi, tekanyo ena e nyane ea oksijene, eo hangata e bitsoang li-free radicals, tse hlaselang lisele tsa rona. Ha nako e ntse e ea, tšenyo ena ea bokellana ha nako e ntse e ea.
Tse bonahalang haholo ke matšoao a botsofali a hlahang letlalong. 'Mele oa rona o na le mokhoa oa ho itšireletsa o lokisang tšenyo e entsoeng liseleng tsa rona ke li-free radical, empa ha li-free radical li bokellana ka potlako ho feta kamoo lisele tsa 'mele li ka li lokisang kateng, letlalo lea tsofala butle-butle.
Setšoantšo se kaholimo ke lisele tsa 'mele tsa rona tsa letlalo, u ka bona ka ho hlaka hore karolo e ka holimo ea letlalo e lefifi 'me karolo e ka tlase ea letlalo e khanya hanyane, karolo ea letlalo ke moo re hlahisang collagen, 'me lisele tse hlahisang collagen li bitsoa fibroblasts, e leng mechine e etsang collagen.
Li-fibroblast tse bohareng ba setšoantšo ke li-fibroblast, 'me tepo ea sekho e li potileng ke collagen. Collagen e hlahisoa ke li-fibroblast, 'me letlalo le lenyenyane ke marang-rang a collagen a mahlakore a mararo le a lohiloeng ka thata, 'me li-fibroblast li hula ka matla likhoeleng tsa collagen ho fa letlalo le lenyenyane sebopeho se felletseng le se boreleli.
'Me letlalo la khale, li-fibroblast le khokahano ea collagen pakeng tsa ho qhalana ha li-fibroblast tse tsofalang hangata li tla hana ho kenella ha collagen, ha nako e ntse e ea, letlalo le lona le ile la qala ho tsofala, sena ke seo re atisang ho se bua ka botsofali ba letlalo, re rarolla joang oxidation ea letlalo e amoheloang?
Ntle le ho ela hloko haholoanyane setlolo sa letsatsi, re ka sebelisa tse ling tse nang le vithamine A, vithamine E, ferulic acid, resveratrol le metsoako e meng ea lihlahisoa tsa tlhokomelo ea letlalo; hangata re ka boela ra ja litholoana le meroho e mebala e khanyang haholoanyane, joalo ka tamati, tamati e ruile ka lycopene.
E ka monya oksijene hantle mme ya thibela kgatello ya oxidative, o ka boela wa ja broccoli e ngata, broccoli e na le karolo e bitswang oli ya mosetareta glycosides, kamora ho ja motsoako ona, di tla bolokwa letlalong, e le hore disele tsa letlalo di kgone ho itshireletsa, ditholwana le meroho ena di ka kgothaletsa ho hanyetsa disele ho tsofala.
Ntlha ea boraro ea bohlokoa ka ho fetisisa botsofaling ba letlalo
Ho glycation ea letlalo
Ka mantsoe a profeshenale, glycation e bitsoa karabelo ea glycosylation e seng ea enzymatic kapa karabelo ea Melad. Molao-motheo ke hore ho fokotsa tsoekere ho tlama liprotheine ha ho se na li-enzyme; ho fokotsa tsoekere ho ka fetoloa haholo ka liprotheine, 'me ho fokotsa tsoekere le liprotheine ho feta karabelong e telele ea oxidation, dehydrogenation, le rearrangment, e leng se fellang ka tlhahiso ea lihlahisoa tsa glycosylation tsa morao-rao, kapa AGEs ka bokhutšoanyane.
AGE ke sehlopha sa litšila tse sa fetoheng, tse sootho bo bosehla, tse amanang le baeloji tse sa tšabeng timetso ea li-enzyme, 'me ke e 'ngoe ea mabaka a ka sehloohong a botsofali ba batho. Ha re ntse re tsofala, AGE lia bokellana 'meleng, e leng se lebisang keketsehong ea ho thatafala ha mabota a ka hare a methapo ea mali, ho se leka-lekane ha metabolism ea masapo ho lebisang ho osteoporosis, le timetso ea collagen le likhoele tsa elastin ka har'a dermis ho lebisang ho tsofaleng ha letlalo. Botsofali ba letlalo bo bakoang ke glycation bo akaretsoa polelong e le 'ngoe: tsoekere e senya liprotheine tse phetseng hantle 'me e fetola mehaho e mecha ea protheine hore e be mehaho ea khale ea protheine, e lebisang ho tsofaleng le tahlehelong ea ho tenyetseha ha collagen le likhoele tsa elastiki ka har'a dermis.
Nako ea poso: Mots'eanong-29-2024
