Litlolo tse Tšoeufatsang leMmalaMetabolism
Melanin anabolism e arotsoe ka linako tse fapaneng. Bo-rasaense ba lumela hore hoa khoneha ho ithuta lintho tse soeufatsang 'mele le ho sebetsa linakong tse fapaneng tsa metabolism.
(1) Mokhahlelo oa pele oa tlhahiso ea melanin
① E sitisa phetolelo le/kapa glycosylation ea tyrosinase; ② E thibela balaoli ho thehoeng ha tyrosinase; ③ Taolo ea tyrosinase kamora ho ngolisoa.
(2) Nako ea tlhahiso ea melanin
Jwalo ka enzyme ya bohlokwa le enzyme e fokotsang sekgahla bakeng sa tlhahiso ya melanin, dithibela-tyrosinase ke tataiso e ka sehloohong ya dipatlisiso le ntshetsopele hajwale. Kaha boholo ba dithibela-tšoeu tse kang di-phenol le di-catechol di tshwana ka sebopeho le tyrosine le dopa, dithibela-tšoeu tse hlahlobilweng hangata di arolwa e le dithibela-tšoeu tse sa qothisaneng lehlokoa kapa tse qothisanang lehlokoa tsa tyrosinase.
(3) Mokhahlelo oa morao oa tlhahiso ea melanin
①E thibela phetiso ea melanosome; lintho tse nang le phello ea thibelo ea serine protease, tse kang rwj-50353, li qoba ka ho feletseng pigmentation e bakoang ke UBV e bakoang ke UBV; soybean trypsin inhibitor e na le phello e totobetseng ea ho soeufatsa empa ha e na phello chefong ea lisele tsa pigment; Niacinamide, e ka sitisa phetiso ea melanocyte pakeng tsa melanocyte le keratinocyte; ② Ho hasana ha melanin le metabolism, α-hydroxy acid, free fatty acid le retinoic acid, li hlohlelletsa nchafatso ea lisele le ho khothalletsa ho tlosoa ha melatinocyte tse melaninized.
Ho bohlokoa ho hlokomela hore lipatlisiso le ts'ebeliso ea lintho tse soeufatsang tse thehiloeng ho metabolism ea melanin e boletsoeng ka holimo ha lia lokela ho thibela le ho phekola li-plaque tsa botsofali. Kaha mokhoa oa ho thehoa ha li-plaque tsa botsofali o amana le ho thehoa ha lipofuscin, lintho tse sebetsang tsa antioxidative li sebelisoa hangata ho liehisa le ho khutlisetsa li-plaque tsa botsofali morao.
Nako ea poso: Phupu-29-2022
